Hydroxypropyl Beta-Cyclodextrin (HPBCD) | Premium Molecular Inclusion Vehicle for Maximum Solubility & Bioavailability
1. Product Overview & Value Proposition
Hydroxypropyl Beta-Cyclodextrin (HPBCD, CAS: 128446-35-5) is a chemically modified cyclic oligosaccharide derived from natural starch via enzymatic conversion and targeted etherification. Featuring a characteristic torus-like ring structure with a lipophilic internal cavity and a hydrophilic external surface, Hydroxypropyl Beta-Cyclodextrin powder forms stable host-guest inclusion complexes with poorly water-soluble molecules. As a cornerstone solubility enhancement raw material, it allows sports nutrition and nutraceutical formulators to dramatically accelerate dissolution kinetics, enhance membrane permeation, and eliminate crystalline agglomeration in solid, liquid, and powder formulations.
As a specialized bulk hydroxypropyl beta-cyclodextrin manufacturer and direct HPBCD CAS 128446-35-5 supplier, we deliver strictly controlled substitution grades tailored to maximize host-guest complexation efficiency. Beyond supplying premium-grade bioavailability enhancer excipient materials, we empower international brands with streamlined commercial flexibility: agile low MOQ procurement for bench-top pilot batches, seamless multi-ingredient shipping consolidation, and dedicated China-wide raw material sourcing assistance.
2. Product Specifications (Analytical Quality)
| Test Item | Specification Standard (Oral / Food Grade) | Test Method |
|---|---|---|
| Identification (IR / TLC) | Conforms to Reference Standard | USP / EP Standard |
| Assay (Purity on Dry Basis) | 98.0% – 102.0% | HPLC-RI |
| Molar Substitution (MS) | 0.60 – 0.90 (DS: 4.0 – 9.0) | 1H-NMR |
| Appearance | White to almost white powder, odorless | Visual / Organoleptic |
| Clarity & Color of Solution | Clear, colorless (10% w/v in water) | Spectrophotometric |
| Betacyclodextrin Residual | ≤ 1.0% | HPLC |
| Propylene Glycol Residual | ≤ 0.5% | GC |
| Loss on Drying | ≤ 5.0% | Gravimetric (105°C) |
| Heavy Metals (Pb) | < 10 ppm | ICP-MS |
| Microbiological Limits | Total Plate Count ≤ 1,000 CFU/g | USP/EP Standard |
3. Functional Applications (Mechanism of Action)
The technological dominance of Hydroxypropyl Beta-Cyclodextrin as an advanced carrier agent stems from its molecular inclusion properties:
- Aqueous Solubility Enhancement: Encapsulates hydrophobic functional actives inside its 6.0–6.5 Å non-polar cavity, elevating effective aqueous solubility up to hundreds of times over native crystalline forms.
- Accelerated In Vivo Bioavailability: Prevents self-aggregation of lipophilic botanical extracts in the gastrointestinal tract, enabling uniform dispersion across mucosal epithelial surfaces.
- Chemical & Thermal Stabilization: Shields labile phytochemical actives against environmental photo-oxidation, thermal degradation, and premature hydrolytic decomposition.
- Organoleptic Masking: Entraps intensely bitter, astringent, or pungent active moieties, facilitating the development of palatable functional liquids, chewable tablets, and drink mixes.
4. Formulation Combinations
Dramatically improve active performance by pairing our Hydroxypropyl Beta-Cyclodextrin with hydrophobic ingredients from our catalog:
- The Ecdysteroid Performance Complex: Our Hydroxypropyl Beta-Cyclodextrin + Ajuga Turkestanica Extract (Turkesterone 10%-20%) + Cyanotis Extract (Ecdysterone 90%-98%). A breakthrough inclusion matrix widely utilized in premium sports nutrition to overcome the natural dissolution limits of botanical ecdysteroids.
- The Advanced Polyphenol Longevity Stack: Our Hydroxypropyl Beta-Cyclodextrin + Resveratrol (99%) + Coenzyme Q10 (Ubiquinone). An optimized formulation engineered to enhance the systemic absorption and cellular delivery of core anti-aging actives.
5. Why Choose Us As Your Long-Term Functional Ingredient Partner?
- Flexible Low MOQ Policy: Eliminate inventory bottlenecking. We support formulation pilots and scale-up manufacturing with low minimum order quantities starting from 1 kg up to recurring multi-ton container programs.
- Comprehensive Functional Catalog: Consolidate your functional excipients alongside standardized plant extracts, amino acids, and minerals into unified freight shipments to lower logistics overhead.
- Value-Added China Sourcing Service: Beyond our core cyclodextrin production lines, our technical team works on the ground to audit facilities, evaluate analytical COAs, and secure specialized raw materials across China tailored to your project criteria.
6. Quality & Supply Chain Assurance
- Strict Degree of Substitution Control: Synthesized with precise hydroxypropylation control to ensure predictable complexation behavior and uniform molecular weight distribution batch after batch.
- Low Residual Impurity Profiles: Thoroughly purified to minimize free beta-cyclodextrin, free propylene glycol, and heavy metal residues below international pharmacopeia limits.
- Durable Protective Packaging: Packed in heat-sealed multi-layer aluminum barrier bags and tamper-evident 25 kg fiber drums to prevent ambient moisture absorption during transoceanic shipping.
7. FAQ
Q1: What is the main difference between native Beta-Cyclodextrin and Hydroxypropyl Beta-Cyclodextrin (HPBCD)?
A1: Native Beta-Cyclodextrin has very limited aqueous solubility (~1.85 g/100 mL at 25°C). Hydroxypropyl substitution disrupts the crystalline hydrogen bonding, increasing aqueous solubility to over 50 g/100 mL and providing a significantly higher safety profile for oral dietary consumption.
Q2: Why is HPBCD widely formulated with Turkesterone and Ecdysterone?
A2: Both Turkesterone and Ecdysterone are lipophilic steroids with low natural water solubility. Complexing them with Hydroxypropyl Beta-Cyclodextrin forms a water-soluble inclusion structure that enhances dissolution rate and digestive absorption efficiency.
Q3: What is the minimum order quantity for bulk HPBCD powder?
A3: As a flexible low MOQ functional excipient distributor, our orders start as low as 1 kg for benchtop pilot trials and scale seamlessly to full metric-ton commercial batches.
8. References
- PubChem: 2-Hydroxypropyl-beta-cyclodextrin Compound Summary – National Center for Biotechnology Information.
- PubMed Central: Cyclodextrins in Drug Delivery and Dietary Formulations: Solubilization, Complexation, and Bioavailability Enhancement – National Institutes of Health research database.
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