1. Product Overview
Andrographolide is the primary bioactive labdane diterpenoid lactone isolated from the traditional botanical Andrographis paniculata (commonly known as Green Chirayta or “King of Bitters”). Renowned for its pronounced bitter profile and powerful biological activities, Andrographolide has become a cornerstone raw material in modern nutraceuticals, functional foods, and pharmaceutical R&D.
For B2B formulators and brand owners, our bulk Andrographolide offers exceptional purity, high batch-to-batch consistency, and full traceability, empowering you to create high-efficacy immune and respiratory support products for global markets.
2. Product Specifications
*Andrographolide 5%-98%
| Item | Specification Standard |
|---|---|
| Botanical Source | Andrographis paniculata (Leaves / Aerial Parts) |
| CAS Number | 5508-58-7 |
| Molecular Formula | C20H30O5 |
| Molecular Weight | 350.45 g/mol |
| Assay (Purity) | ≥ 98.0% (by HPLC) |
| Appearance | White or off-white crystalline powder |
| Melting Point | 229–232 °C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition (Ash) | ≤ 0.3% |
| Heavy Metals | < 10 ppm |
| Lead (Pb) | < 1.0 ppm |
| Arsenic (As) | < 1.0 ppm |
| Cadmium (Cd) | < 0.5 ppm |
| Mercury (Hg) | < 0.1 ppm |
| Total Plate Count | < 1,000 CFU/g |
| Yeast & Mold | < 100 CFU/g |
| E. Coli & Salmonella | Negative |
| Solubility | Slightly soluble in methanol, ethanol; practically insoluble in water |
3. Functional Applications
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Immune Health Formulations: Widely utilized in dietary supplements designed to support natural immune defense mechanisms and seasonal wellness.
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Respiratory Support: Known for traditional and modern applications targeting upper respiratory tract comfort and mucosal health.
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Anti-inflammatory & Antioxidant Research: Frequently investigated for its cellular pathways influencing inflammatory cytokine modulation.
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Pharmaceutical Intermediates: Serves as a high-grade active raw material for advanced drug discovery and semi-synthetic derivatives.
4. Formulation Combinations
To maximize consumer compliance and synergistic health outcomes, Andrographolide can be effectively paired with:
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Echinacea Extract & Elderberry Extract: For comprehensive, multi-action seasonal immune-defense capsules.
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Vitamin C & Zinc Picolinate: Classic micronutrient combination to enhance overall white blood cell function and immune resilience.
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Ginger Extract or Peppermint Oil: To mitigate the intense bitter note of pure diterpenoid lactones in oral delivery systems and improve gastrointestinal tolerance.
5. Market Opportunities
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Rising Demand for Natural Immune Solutions: Global consumer shifts toward preventive healthcare have accelerated the demand for standardized botanical extracts backed by scientific literature.
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Clean-Label & High-Potency Formulations: Brands are moving away from crude herb powders toward high-purity isolated active markers like 98% Andrographolide, allowing for smaller capsule sizes and precise dosing.
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B2B Contract Manufacturing: Ideal for supplement brands looking to introduce premium, science-backed botanical SKUs into competitive retail and practitioner channels.
6. Quality & Supply
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Stringent Quality Assurance: Tested via state-of-the-art HPLC and GC-MS equipment; every commercial lot ships with an official Certificate of Analysis (CoA).
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Packaging & Storage: Packaged in food-grade aluminum foil bags or double polyethylene liners inside fiber drums (25kg/drum); store in a cool, dry, dark environment away from direct light and moisture.
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Global Logistics: Reliable, compliant international air and ocean freight solutions designed for raw material importers and contract manufacturers.
7. FAQ (Frequently Asked Questions)
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Q1: What is the recommended dosage for finished dietary supplements using Andrographolide?
A1: Dosages typically range from 100mg to 400mg per daily serving of standardized extract, depending on the target formulation and regulatory guidelines of the destination market.
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Q2: Is this product water-soluble?
A2: Pure Andrographolide has very low water solubility. It is typically formulated into capsules, tablets, or oil/lipid-based delivery systems.
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Q3: Do you provide free sample quantities for R&D testing?
A3: Yes, we supply gram-scale sample batches for laboratory analysis and formulation testing. Contact our sales team to request a sample.
8. References
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Andrographolide | C20H30O5 – PubChem.
(Provides comprehensive chemical structure, physical characteristics, and molecular identifiers.)
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National Library of Medicine (PubMed)
Andrographolide Research & Pharmacological Mechanisms – PubMed.
(Peer-reviewed literature database covering cellular mechanisms, immune modulation, and clinical evaluations.)
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Andrographolide Overview – ScienceDirect Topics.
(Summarizes pharmacological properties, pharmacokinetics, and botanical extraction methodologies.)
