Product Overview
Lithospermum Extract is derived from the dried roots of Lithospermum erythrorhizon Sieb. et Zucc., a traditional botanical deeply valued in East Asian herbalism for its remarkable restorative properties. The primary bioactive naphthoquinone derivative responsible for its intense reddish-purple hue and powerful physiological activity is Shikonin.
Promaxbio offers pharmaceutical and cosmetic-grade Lithospermum Extract standardized to a minimum purity of 30.0% Shikonin using High-Performance Liquid Chromatography (HPLC). Manufactured under stringent cGMP guidelines, our raw material provides B2B cosmetic formulators, skincare brands, and advanced supplement manufacturers with a potent bioactive ingredient tailored for anti-inflammatory, antimicrobial, and skin-barrier repair applications.
Product Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Lithospermum Extract (Shikonin) | Visual |
| Botanical Name | Lithospermum erythrorhizon Sieb. et Zucc. | Taxonomic Identity |
| Active Marker | Shikonin ≥ 30.0% | HPLC |
| Part Used | Root | Visual |
| Appearance | Dark reddish-purple crystalline powder | Organoleptic |
| Odor & Taste | Characteristic, bland | Organoleptic |
| Particle Size | 100% pass 80 mesh | USP <786> |
| Loss on Drying | ≤ 5.0% | USP <731> |
| Heavy Metals (as Pb) | ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 2 ppm) | ICP-MS |
| Microbiological Profile | Total Plate Count < 1,000 CFU/g; Yeast & Mold < 100 CFU/g; E. coli / Salmonella Negative | USP <2021/2022> |
Functional Applications
- Powerful Anti-Inflammatory Action: Inhibits inflammatory mediators and helps soothe irritated, red, or sensitive skin conditions.
- Wound Healing & Tissue Repair: Stimulates granulation tissue formation and accelerates cellular regeneration for skin barrier recovery.
- Antimicrobial & Acne Care: Exhibits strong broad-spectrum inhibitory activity against common skin bacteria, making it ideal for blemish-prone formulations.
- Antioxidant Defense: Scavenges free radicals and protects dermal extracellular matrix components from oxidative degradation.
Formulation Combinations
- Anti-Acne & Blemish Stacks: Synergizes effectively with Salicylic Acid, Tea Tree Oil, and Centella Asiatica Extract for targeted spot treatments.
- Barrier Repair & Soothing Creams: Pairs seamlessly with Ceramides, Panthenol, and Allantoin for post-procedure or sensitive skin recovery balms.
- Natural Color & Active Cosmeceuticals: Utilized in premium organic skincare lines for its dual benefit as a high-performance active and a natural pigment.
Market Opportunities
- The Clean Beauty & Botanical Boom: High consumer demand for scientifically validated, plant-derived actives replacing synthetic anti-inflammatory agents.
- Niche Problem-Skin Solutions: Exceptional market potential in specialized cosmetics addressing eczema-prone skin, redness, and rapid skin recovery.
- High Potency Standardization: Formulators increasingly seek 30% high-purity Shikonin to ensure consistent clinical efficacy and minimal inclusion rates.
Quality & Supply Assurance
Promaxbio guarantees strict cGMP-compliant manufacturing for every commercial batch of Lithospermum Extract. Our material undergoes rigorous HPLC assay testing, heavy metal screening via ICP-MS, and complete microbiological verification. Packaged in light-resistant, food-grade polyethylene bags inside secure fiber drums, our product is fully protected against moisture and degradation during storage and global transit.
Frequently Asked Questions (FAQ)
Q1: What are the main active components in Lithospermum Extract?
A: The primary bioactive constituents are naphthoquinone derivatives, with Shikonin being the most prominent marker quantified via HPLC.
Q2: What is the typical inclusion rate in cosmetic formulations?
A: Depending on the specific application (e.g., soothing balms or spot serums), typical inclusion rates range from 0.1% to 1.0% of the finished formulation.
References & Scientific Literature
- Andujar, I., et al. (2013). Shikonin: An ancient plant-derived naphthoquinone active in cancer and inflammation. Current Pharmaceutical Design, 19(21), 3847–3862. DOI: 10.2174/1381612811319210011
- Chen, X., et al. (2002). Overview of pharmacological activities of Shikonin and its derivatives. Phytotherapy Research, 16(3), 199–209. DOI: 10.1002/ptr.1092
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