Product Overview
Syrian Rue Seed Extract is derived from the seeds of Peganum harmala L., a perennial flowering shrub traditionally utilized in ethnobotanical medicine across the Middle East, Central Asia, and the Mediterranean. Renowned for its rich content of naturally occurring beta-carboline alkaloids—predominantly Harmine and Harmaline—this botanical extract is widely researched for its enzymatic inhibitory properties, neuroprotective actions, and broad-spectrum antimicrobial activity.
Promaxbio offers premium-grade Syrian Rue Seed Extract standardized via high-performance liquid chromatography (HPLC) to guarantee consistent active alkaloid concentrations. Sourced from selectively harvested seeds, our extract provides functional ingredient manufacturers and researchers with a reliable, high-purity raw material suitable for specialized wellness, cognitive research, and topical formulations.
Product Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Syrian Rue Seed Extract | Visual |
| Botanical Name | Peganum harmala L. | Taxonomic Identity |
| Active Compounds | Total Harmala Alkaloids (Harmine / Harmaline) ≥ 10.0% – 98.0% | HPLC |
| Part Used | Seed | Visual |
| Appearance | Fine yellow-brown to light-yellow crystalline powder | Organoleptic |
| Odor & Taste | Characteristic, bitter | Organoleptic |
| Particle Size | 100% pass 80 mesh | USP <786> |
| Loss on Drying | ≤ 5.0% | USP <731> |
| Total Ash | ≤ 5.0% | USP <561> |
| Heavy Metals (as Pb) | ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 2 ppm, Cd ≤ 1 ppm, Hg ≤ 0.1 ppm) | ICP-MS |
| Microbiological Profile | Total Plate Count < 1,000 CFU/g; Yeast & Mold < 100 CFU/g; E. coli / Salmonella Negative | USP <2021/2022> |
Functional Applications
- Neurochemical & Cognitive Research: The primary beta-carbolines (harmine and harmaline) function as potent, reversible inhibitors of Monoamine Oxidase A (RIMA), making the extract a valuable benchmark compound in neurochemical and neurotransmitter studies.
- Cellular Defense & Antioxidant Activity: Demonstrates marked radical-scavenging capabilities, protecting cellular integrity against oxidative stress and lipid peroxidation.
- Topical & Scalp Revitalizing Formulations: Due to its traditional application in hair-care rituals, the extract is actively incorporated into botanical scalp serums and clarifying cosmetic solutions targeting microbial balance and follicle vitality.
- Antimicrobial & Preservative Research: Exhibits intrinsic inhibitory effects against various bacterial and fungal strains, serving as a functional natural active in technical personal care applications.
Formulation Combinations
- Cosmetic Scalp Tonics: Combines synergistically with Rosmarinus officinalis (Rosemary) Leaf Extract, Caffeine, and Saw Palmetto Extract to formulate stimulating hair and scalp lotions.
- Topical Clarifying Blends: Pairs effectively with Tea Tree Oil and Niacinamide for purifying skin care matrices aimed at problematic and blemish-prone complexions.
- Botanical Synergy Systems: Formulated alongside gentle calming botanicals (such as Chamomile Extract or Passionflower) in laboratory-scale phytotherapeutic research settings.
Market Opportunities
- Specialized Botanical Research: Rising academic and institutional interest in neuroprotective secondary metabolites has elevated the commercial demand for standardized beta-carboline extracts.
- Scalp Health & Anti-Hair Fall Formulations: The hair wellness category continues to seek traditional botanical actives backed by contemporary phytochemistry, positioning Peganum harmala as a distinctive hero ingredient.
- Customizable Alkaloid Titration: B2B formulators can leverage customized extraction ratios (from full-spectrum 10:1 extracts up to 98% isolated harmine) to address diverse product requirements.
Quality & Supply Assurance
At Promaxbio, each batch of Syrian Rue Seed Extract is manufactured under strict cGMP conditions. Our quality control protocol includes:
- Verified Botanical Authenticity: TLC and HPLC chromatographic fingerprinting ensure zero adulteration and accurate botanical species verification.
- Solvent & Residue Monitoring: Extracted using water and food-grade ethanol, followed by complete solvent recovery conforming to USP/EP residual solvent limits.
- Packaging & Storage: Supplied in double-sealed pharmaceutical-grade polyethylene liner bags inside 25 kg fiber drums. Store in a cool, dry area away from direct sunlight and heat.
Frequently Asked Questions (FAQ)
Q1: What are the primary active markers in Syrian Rue Seed Extract?
A: The principal bioactives are beta-carboline alkaloids, specifically Harmine, Harmaline, and small amounts of Tetrahydroharmine, standardized by HPLC analysis.
Q2: What extraction solvents are utilized in manufacturing?
A: We use a closed-loop hydroalcoholic (ethanol and purified water) extraction system, ensuring zero toxic solvent residues in the final finished powder.
Q3: What documentation is provided with wholesale orders?
A: Promaxbio provides a comprehensive documentation package with every commercial batch, including the Certificate of Analysis (COA), Safety Data Sheet (SDS), Technical Data Sheet (TDS), and Non-GMO/BSE-TSE declarations.
References & Scientific Literature
- Moloudizargari, M., Mikaili, P., Aghajanshakeri, S., Asghari, M. H., & Shayegh, J. (2013). Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy Reviews, 7(14), 199–212. DOI: 10.4103/0973-7847.120524
- Herraiz, T., González, D., Ancín-Azpilicueta, C., Arán, V. J., & Guillén, H. (2010). beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48(3), 839–845. DOI: 10.1016/j.fct.2009.12.019
